Dr Mutalithas graduated from the University of Sheffield, School of Medicine in the UK in 1997. He worked as a junior doctor in hospitals in Sheffield, London, Manchester and Leicester and became a member of the Royal College of Physicians of London in 2000.

He trained in Respiratory Medicine at the Central Middlesex Hospital in London, the North West Lung Centre in Manchester and the Manchester Royal Infirmary. He spent 2 years as a clinical research fellow studying the immune processes within the Asthmatic lung and was awarded an MD in 2008 and has had his work published in peer-review journals. He worked as a Consultant Respiratory Physician in London before moving to Australia in 2009. He has worked in a number of hospitals in Brisbane and became a fellow of the Royal Australasian College of Physicians in 2010.

Dr Mutalithas had been consulting at the John Flynn Private Hospital since 2011. He maintains knowledge and expertise in a range of medical disciplines and is also credentialed in General Medicine and contributes to the General Medical Services at the Robina Public Hospital, where he is also a member of the teaching faculty for undergraduate medical students.